No predicted properties have been calculated for this compound. In infrared spectroscopy, samples are analyzed by grinding with powdered potassium bromide and pressing into a disc. The KB has an ionic link. KBr is a stable compound at room temperature. In January 1874, Dr. Francis Anstie reported a case of epilepsy "Cured"by potassium bromide, in which the attacks were completely interrupted and remained absent long after the discontinuation of the medicine. Madrid, Manuel Álvarez Printing House, Studios, 9, Norton Manning, P., (April-1875), Journal of Mental Science. The therapeutic index (ratio of effectiveness to toxicity) for bromide is small. In the analysis of infrared samples, the use of KBr cells to contain the sample is very practical, due to its transparency that does not interact with the incident radiation. It was widely used in the pharmaceutical industry, specifically to prepare antiepileptic drugs, since the bromide ion is anticonvulsant. [7] Bromide's exceedingly long half life in the body made it difficult to dose without side effects. At the time, it was commonly thought that epilepsy was caused by masturbation. Each molecule has a unique light absorbance profile within the infrared (IR) spectrum. However, it is currently restricted to veterinary use. Other uses for potassium bromide are in clear completion fluids in the petroleum industry, as a pharmaceutical intermediate, and in the manufacture of fibers. As with other antiepileptics, sometimes even therapeutic doses (3 to 5 grams per day, taking 6 to 8 weeks to reach stable levels) may give rise to intoxication. Incompatible with strong oxidizing agents, strongacids, bromine trifluoride and bromine trichloride. The halogen completes its octet (eight electrons in its last energy level), which allows a greater stability in its internal energy. In this type of link there is an electrostatic union between the charged species, so the force between them is not very high; hence its facility for dissociation in water. This reaction is important for the manufacture of silver bromide for photographic film: Aqueous bromide Br− also forms complexes when reacted with some metal halides such as copper(II) bromide: A traditional method for the manufacture of KBr is the reaction of potassium carbonate with an iron(III, II) bromide, Fe3Br8, made by treating scrap iron under water with excess bromine:[4], The anticonvulsant properties of potassium bromide were first noted by Sir Charles Locock at a meeting of the Royal Medical and Chirurgical Society in 1857. In a dilute aqueous solution, potassium bromide tastes sweet, at higher concentrations it tastes bitter, and tastes salty when the concentration is even higher. Due to its high solubility and hygroscopic nature it must be kept in a dry environment. The physical aspect is a white crystalline solid and is hygroscopic; that is, it absorbs water from the medium. [citation needed]. Potassium bromide (KBr) is a salt, widely used as an anticonvulsant and a sedative in the late 19th and early 20th centuries, with over-the-counter use extending to 1975 in the US. Potassium bromide (KBr) is a salt, widely used as an anticonvulsant and a sedative in the late 19th and early 20th centuries, with over-the-counter use extending to 1975 in the US. It can react with other halogenated compounds such as chlorinated compounds, so that displacement of bromine by chlorine can occur. [10], Except where otherwise noted, data are given for materials in their, Serotonin antagonists and reuptake inhibitors,, GABAA receptor positive allosteric modulators, Articles with changed ChemSpider identifier, Pages using collapsible list with both background and text-align in titlestyle, Articles containing unverified chemical infoboxes, Wikipedia articles needing clarification from August 2013, Articles with unsourced statements from October 2020, Articles with unsourced statements from May 2016, Creative Commons Attribution-ShareAlike License. The plates are transparent to infrared light and do not introduce any line on the spectra. In high concentration, potassium bromide strongly irritates the gastric mucous membrane, causing nausea and sometimes vomiting (a typical effect of all soluble potassium salts). These effects are mainly due to the properties of the potassium ion—sodium bromide tastes salty at any concentration. Coordination geometry: octahedral. IDENTIFICATION AND USE: Potassium bromide is a solid. Potassium bromide is used in veterinary medicine to treat epilepsy in dogs, either as first-line treatment or in addition to phenobarbital, when seizures are not adequately controlled with phenobarbital alone. Click to predict properties on the Chemicalize site, For medical information relating to Covid-19, please consult the, ACD/Labs Percepta Platform - PhysChem Module, Compounds with the same molecular formula, Search Google for structures with same skeleton, Freely soluble in water. [8] These indications include severe forms of generalized tonic-clonic seizures, early-childhood-related tonic–clonic seizures, and also severe myoclonic seizures during childhood.