¾A piece of filter paper is placed on surface followed by a layer of clean https://doi.org/10.1016/j.powtec.2019.05.027. The aim of this work is to study for the first time the existence and behaviour of the percolation thresholds in ternary pharmaceutical tablets. The capability of multivariate analysis to predict the drug loading threshold was also tested. 2. In conclusion, percolation theory was able to predict the maximum acceptable drug loading for this binary system of API and excipient. Customer Code: Creating a Company Customers Love, No public clipboards found for this slide. "Certain pharmaceutical preparations are prepared by … As of this date, Scribd will manage your SlideShare account and any content you may have on SlideShare, and Scribd's General Terms of Use and Privacy Policy will apply. Now customize the name of a clipboard to store your clips. It is proved that stationary menstruum (menstruum remaining in contact with the drug) dissolves more menstruum is required to exhaust the drug when simple percolation is used. ¾Packed evenly into the percolator. Hassan MuJtaba ScienceDirect ® is a registered trademark of Elsevier B.V. ScienceDirect ® is a registered trademark of Elsevier B.V. The bulk and tapped densities of the mixtures as well as the hardness and in-vitro release behaviour of the tablets have been studied. This Video Lecture covers the most important pharmaceutics topics like Percolation, stage used in percolation and types of percolation. Pharmaceutical preparations The process of “EXTRACTION” 2. You can change your ad preferences anytime. By continuing you agree to the use of cookies. 43-E-14. The KCl percolation threshold has been estimated in the range 0.26–0.31 of total porosity. This theoretical percolation coefficient was proposed for binary mixtures in which one of the substances compacts well and the second is poorly compactable, which would apply to the ibuprofen/MCC blends. Calculated percolation threshold matches drug loading to form infinite cluster. Percolation (Exhaustive Extraction) 2.1: Process ¾Organized vegetable drug in a suitably powdered form. Copyright © 2020 Elsevier B.V. or its licensors or contributors. Modelling percolation threshold allows identification of critical drug loadings. Extraction in pharmaceutics 1. … !Percolation 2. Principal component analysis was unable to identify the threshold, but provided an overview of the changes of the analysed properties as ibuprofen drug loading increased. The aim of this study was to investigate if percolation theory could be used to predict the drug loading concentration of pharmaceutical tablets, and the relative density of a blend, above which tablet tensile strength is reduced, resulting in the production of unsatisfactory products. 11/14/16 2 COLLEGE+OF+PHARMACY UNIVERSITY+OF+BASRAH Extraction Methods for Preparing Solutions "The sole purpose of such basic extraction procedures for crude drugs are to obtained the therapeutically desirable portion and eliminate the inert material by treatment with a selective solvent known as the Menstruum. If you wish to opt out, please close your SlideShare account. it helpful for Pharma graduate and diploma students . Copyright © 2020 Elsevier B.V. or its licensors or contributors. If you continue browsing the site, you agree to the use of cookies on this website. On the other hand, the existence of a ‘combined percolation threshold’ of the sum of all the hydrophilic substances, i.e. See our Privacy Policy and User Agreement for details. Presented by: For this purpose, mixtures containing three substances with very different … One of the handicaps for the application of the principles of percolation theory in pharmaceutical systems is the fact that this theory has been developed for binary systems. A range where PVP-CL percolates can be defined between 10 and 30% v/v. Copyright © 1996 Published by Elsevier B.V. https://doi.org/10.1016/0378-5173(96)04603-0. If you continue browsing the site, you agree to the use of cookies on this website. Dissolution measurements confirmed experimentally a percolation threshold in agreement with that determined using percolation theory and compression data. Across the percolation threshold, a step change in dissolution behaviour occurred, and tablets containing air stream dried MCC showed slower disintegration rates compared to tablets containing spray dried MCC. ScienceDirect ® is a registered trademark of Elsevier B.V. ScienceDirect ® is a registered trademark of Elsevier B.V. Study of percolation thresholds in ternary tablets. By continuing you agree to the use of cookies. This influences the hardness of the tablet. PERCOLATION Presented by: Hassan MuJtaba 43-E-14 2. The application of percolation threshold theory to predict compaction behaviour of pharmaceutical powder blends. 12122012 “EXTRACTION with Special Reference to Maceration” Assigned by Dr. Akhtar Rasool Ph.D-Pharmaceutics Presented by Mudassar Ahmad DPH-FA11-035 “The University of Faisalabad” This methodology could be employed for other binary systems to predict maximum drug loading potential without the need for time consuming and expensive tablet production. For this purpose, mixtures containing three substances with very different hydrophilicity and water-solubility—KCl, polyvinylpyrrolidone cross-linked (PVP-CL) and Eudragit® RS-PM—were prepared and compressed. Slideshare uses cookies to improve functionality and performance, and to provide you with relevant advertising. Percolation theory provides a statistical model which can be used to predict the behaviour of powder blends based on particle-particle interactions. Raman imaging used to visualise drug loading for formation of infinite cluster. Two MCC grades with differing physical properties were investigated, Vivapur® 102 (air streamed dried quality), and Emcocel® 90 (spray dried quality) to test the theory. The model blend studied contained ibuprofen as the API, which exhibits poor flow and compressibility, and microcrystalline cellulose (MCC) as the excipient, which exhibits good flowability and compressibility. See our User Agreement and Privacy Policy. Scribd will begin operating the SlideShare business on December 1, 2020 Looks like you’ve clipped this slide to already. The strong solution of active constituents of drug formed during maceration is displaced by the fresh menstruum when percolation process is started. It was also able to identify differences between blends containing Vivapur® or Emcocel®. The percolation thresholds and the critical mass fractions were also calculated by applying a theoretical value of percolation coefficient previously published (T f =2.7) to the Eq. Blends containing 2.5 to 40% w/w of ibuprofen were compacted at a range of pressures and the values of the powder true density, compaction pressure, tablet envelope density, and tablet tensile strength were used to calculate the percolation thresholds mathematically. But if continuous percolation stage has … Percolation 1. Download : Download high-res image (562KB)Download : Download full-size image. PERCOLATION Learn more. 3. INTRODUCTION ‘per’ means ‘through’ ‘colare’ mean ‘to strain’ Definition The process in which a comminuted drug is extracted of its soluble constituents by the slow passage of suitable solvent through a column of drug. Calculated percolation threshold verified by testing desirable blend properties. The drug loading threshold values predicted with the model (19.08% w/w and 17.76% w/w respectively for Vivapur® 102 and Emcocel® 90) were found to be in good agreement when compared to experimental data and the infinite cluster of drug was visually confirmed on the surface of tablets using Raman imaging. We use cookies to help provide and enhance our service and tailor content and ads.